REVIEW: Revelations that resist prevailing global lies and orthodoxies

Phosphonated polyurethanes that resist calcification.

Cardiovascular implant mineralization involving bioprosthetic materials, such as glutaraldehyde cross linked porcine aortic valves or synthetic materials such as polyurethanes, is an important problem that frequently leads to clinical failure of bioprosthetic heart valves, and complicates long-term experimental artificial heart device implants. Novel, proprietary, calcification resistant polyet...

Four Challenges That Global Health Networks Face

Global health networks, webs of individuals and organizations with a shared concern for a particular condition, have proliferated over the past quarter century. They differ in their effectiveness, a factor that may help explain why resource allocations vary across health conditions and do not correspond closely with disease burden. Drawing on findings from recently concluded studies of eight gl...

Against Orthodoxies in Rabies

Toward antiviral strategies that resist viral escape.

We studied the effect on viral growth of drugs targeting different virus functions using a computer simulation for the intracellular growth of bacteriophage T7. We found that drugs targeting components of negative-feedback loops gain effectiveness against mutant viruses that attenuate the drug-target interaction. The greater inhibition of such mutants than of the wild type suggests a drug desig...

Group representations that resist random sampling

We show that there exists a family of groups Gn and nontrivial irreducible representations ρn such that, for any constant t, the average of ρn over t uniformly random elements g1, . . . , gt ∈ Gn has operator norm 1 with probability approaching 1 as n→∞. More quantitatively, we show that there exist families of finite groups for which Ω(log log |G|) random elements are required to bound the nor...